The Clinical Characterisation Protocol (CCP) is designed for any severe or potentially severe acute infection of public health interest.

It is a standardised protocal that enables data and biological samples to be collected rapidly in a globally-harmonised manner.

The Clinical Characterisation Protocol (CCP) can be used for the rapid, coordinated clinical investigation of confirmed cases of COVID-19.


ISARIC offers a web-based eCRF for the CCP and can host the data. For further information please contact

The resources are free to use. ISARIC supports researchers to retain control of the data and samples they collect.


We ask that ISARIC is acknowledged and informed if you implement the protocol. Ethical approval of the protocol and all necessary operational and financial arrangements are the responsibility of the investigators.






Recruitment under this protocol has previously been initiated in response to Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV) in 2012-2013, Influenza H7N9 in 2013, viral haemorrhagic fever (Ebolavirus) in 2014, Monkeypox & MERS-CoV in 2018, Tick-borne encephalitis virus (TBEV) in 2019 and COVID-19 in 2020.