WHO/ISARIC collaboration for Ebola preparedness – Call for action!

PREPARE & GloPID-R report on the "Reaching out" event is live!

Zika COS Study Online Survey

Zika COS Project and Congenital Infections: A study to develop the Core Outcome Set (COS) for children affected by Zika's Congenital Syndrome Virus or other congenital infections.

Important update on ISARIC Protocols and Data Tools

ZIKAlliance’s Clinical Meeting in Cuba 12-14 August, 2017

Final workshop on conducting clinical research during disease outbreaks

Dr Fernando Bozza to give a talk about international collaboration during the Zika outbreak

Challenges of scientific collaboration during an outbreak: the recent experience with Zika in Brazil

Successful technology transfer of a Zika vaccine developed by Institut Pasteur Shanghai-Chinese Academy of Sciences (IPS-CAS) to Chongqing Zhifei Biological Products Co., Ltd.

Institut Pasteur Shanghai-Chinese Academy of Sciences (IPS-CAS), a partner of the ZIKAlliance consortium, announced that it has entered into a collaborative research agreement with Chongqing Zhifei Biological Products Stock Co., Ltd. (Zhifei) for the clinical studies and commercialization of a recombinant Zika virus subunit vaccine developed by IPS-CAS.

Risk of microcephaly after Zika virus infection in Brazil, 2015 to 2016

The key message from this study is that the large uncertainty around the risk estimate needs to be further investigated because of a) the possible existence of co-factors that are yet to be validated, b) the assumptions that the authors needed to make in the absence of good data for the proportion of women who were infected during pregnancy.

Funding available for the SPSAS in Arbovirology in Brazil

Study of volunteer blood donors in Martinique provides new information about Zika virus infection

This pioneering study provides a precise follow-up of incident cases and seroprevalence in blood donors, and it also provides important insights into the management of blood donations during ZIKV outbreaks and into the natural history of ZIKV infection in adults. It suggests that the study of blood donors during outbreaks of emerging pathogens has become a key element of epidemiological surveillance.

Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses

A study performed by the Institut National de la Santé et de la Recherche Médicale (INSERM) team of Dr Ali Amara (U944, Paris, France) and published in Cell Reports sheds new light on the mechanisms allowing ZIKV to infect cells within the human nervous system. Amara et al. showed that the protein Axl is expressed in a number of brain glial cells and that the entry of ZIKV into these cells requires another protein, Gas6, to act as a bridge between the ZIKV particles and the glial cells.

Global research platforms receive €30M to combat Zika

Global research platforms receive €30M to combat Zika   Oxford --21 October 2016, ISARIC members are part of two successful bids to the European Union’s Horizon 2020 Research and Innovation Programme that will set up multinational and multi-disciplinary research consortia to combat Zika virus (ZIKV) infection and build pandemic preparedness in Latin America and the Caribbean over the next 3 to 5 years, the European Commission announced today.

This week In Global Health Zika virus video

This Week in Global Health or TWiGH presents Global Health Out Loud with Sulzhan Bali & Jessica Taaffe. This week they discuss Zika virus.

Peter Horby: Science in a crisis, fast-forwarding clinical research for Ebola

Video of Professor Peter Horby, the University of Oxford, on how he and his team set up clinical trials in the heart of the Ebola outbreak.

‘Big-data’ to prolong the efficacy of antimalarial treatments

The extent and nature of drug resistance in Plasmodium vivax malaria

Whilst our understanding of drug resistant Plasmodium falciparum is quite well understood, the extent and nature of resistance in Plasmodium vivax parasites is for the most part unknown.

Site Finder application

Are you a research scientist working in Global Health? Or an institution looking for partners to run a clinical trial? Site Finder is for you.

ISARIC Newsletters

International Severe Acute Respiratory and Emerging Infection Consortium newsletters

ISARIC Sample and Data Sharing Policy V4

ISARIC Partnership documents

Documents for seeking ISARIC endorsement for research studies.

ISARIC Membership Forms v2

If you wish to join ISARIC you need to download and submit a membership form. Please download your form here.

ISARIC Governance Framework v.4.2

ISARIC's Governance Framework v.4.2 as reviewed and ratified by ISARIC's Council 3 July 2014.

Prof Peter Piot on Ebola

Professor Peter Piot, LSHTM, talks about Ebola and implications for Africa and understanding future epidemics at the Martin School, University of Oxford, 16th October 2014.

UK Clinical Characterisation Protocol for Severe Emerging Infection v7

Access the WHO/ISARIC Clinical Characterisation Protocol for Severe Emerging Infection (v7), which is currently being rolled out in the UK. Site files for other countries will be made available in due course.

Five keys to improving research costing in low- and middle-income countries

ESSENCE on Health Research have created a good practice document on research costing. It includes a review of the funding practices related to the definition and funding of direct and indirect costs. 

Implementation Research in Health: A Practical Guide from the WHO

This guide, developed by the WHO and released in December 2013, aims to facilitate implementation research in LMICs.

ISARIC-SARI-BSP Adapted Study Documents - Protocols

You can download protocols from a variety of sites implementing the ISARIC-SARI-BSProtocol by selecting the document from the list on the right. 

Singapore SARI BSP Documents

ISARIC/WHO BSP sampling plan and CRF adapted by the Singapore Severe Acute Respiratory Infection Study Group, available for download.

ISARIC Novel Coronavirus CRF Version 1.3

This is the ISARIC case-report form if you wish to use it for cases of human infection with the novel coronavirus (hCoV-EMC).

Bibliography: Articles of Interest for potential nCoV treatment

A bibliography for articles that may be of interest when treating patients diagnosed with novel coronavirus.

ISARIC Novel Coronavirus CRF (Ethics & Regulatory) v 1.0

A CRF aiming to provide feedback on the process to inform future work with ethical committees and regulatory agencies.

ISARIC Funding Opportunities Bulletin January 2013

A collection of funding opportunities nationally, regionally and globally that may be of interest to ISARIC members. Please contact the Secretariat directly to suggest links for the next bulletin.

ISARIC Funding Opportunities Bulletin 2012

Clinical research needs for patients infected with the Novel Coronavirus - Proposals from ISARIC

ISARIC - Inernational Severe Acute Respiratory and Emerging Infection Consortium broadcast a statement outlining proposals for a research agenda with regards to the novel coronavirus, through ProMED on December 8th. The statement includes a description of potential observatinal studies, RCTs, a sampling plan, and suggestions for possible interventions.

ISARIC Newsletter Q4 October 2012

Meeting Summary ISARIC 1st Council Meeting July 2012

1st ISARIC Council Meeting Summary. Includes details on ISARIC's vision, a summary of the meeting proceedings and a list of the next steps ahead.

ISARIC Newsletter Q1 April 2012

ISARIC's Newsletter for the first quarter of 2012, including and update of activities December 2011 - April 2012, a listing of the members of the Executive Committee, Regional Hubs, Working Groups, External Advisors and Secretariat, and a message from ISARIC's Chairman Jeremy Farrar.

ISARIC Governance Framework v 3

ISARIC's Governance Framework describing the oranisational structure and the various tasks of the Executive Committee, Secretariat, Council, Working Groups, Advisory Committee and other entities that form part of ISARIC's governance framework.

ISARIC Membership Forms

ISARIC Membership forms for Full and Individual Membership with instructions.

ISARIC Membership Policy v 2

All networks and individuals wishing to join ISARIC and wanting to participate in the activities of ISARIC's Working Groups must read and sign off the Membership Policy - including our mission statement and the objectives of the consortium. The Membership is applied for by filling out, signing, and submitting a membership form - either for Full Membership (Networks) or Individual Membership (individuals who are not, yet, eligible to represent networks). The membership is free of charge.