Zika COS Project and Congenital Infections: A study to develop the Core Outcome Set (COS) for children affected by Zika's Congenital Syndrome Virus or other congenital infections.
Challenges of scientific collaboration during an outbreak: the recent experience with Zika in Brazil
Successful technology transfer of a Zika vaccine developed by Institut Pasteur Shanghai-Chinese Academy of Sciences (IPS-CAS) to Chongqing Zhifei Biological Products Co., Ltd.by ZIKAlliance
Institut Pasteur Shanghai-Chinese Academy of Sciences (IPS-CAS), a partner of the ZIKAlliance consortium, announced that it has entered into a collaborative research agreement with Chongqing Zhifei Biological Products Stock Co., Ltd. (Zhifei) for the clinical studies and commercialization of a recombinant Zika virus subunit vaccine developed by IPS-CAS.
The key message from this study is that the large uncertainty around the risk estimate needs to be further investigated because of a) the possible existence of co-factors that are yet to be validated, b) the assumptions that the authors needed to make in the absence of good data for the proportion of women who were infected during pregnancy.
This pioneering study provides a precise follow-up of incident cases and seroprevalence in blood donors, and it also provides important insights into the management of blood donations during ZIKV outbreaks and into the natural history of ZIKV infection in adults. It suggests that the study of blood donors during outbreaks of emerging pathogens has become a key element of epidemiological surveillance.
A study performed by the Institut National de la Santé et de la Recherche Médicale (INSERM) team of Dr Ali Amara (U944, Paris, France) and published in Cell Reports sheds new light on the mechanisms allowing ZIKV to infect cells within the human nervous system. Amara et al. showed that the protein Axl is expressed in a number of brain glial cells and that the entry of ZIKV into these cells requires another protein, Gas6, to act as a bridge between the ZIKV particles and the glial cells.
Global research platforms receive €30M to combat Zika Oxford --21 October 2016, ISARIC members are part of two successful bids to the European Union’s Horizon 2020 Research and Innovation Programme that will set up multinational and multi-disciplinary research consortia to combat Zika virus (ZIKV) infection and build pandemic preparedness in Latin America and the Caribbean over the next 3 to 5 years, the European Commission announced today.
This Week in Global Health or TWiGH presents Global Health Out Loud with Sulzhan Bali & Jessica Taaffe. This week they discuss Zika virus.
Video of Professor Peter Horby, the University of Oxford, on how he and his team set up clinical trials in the heart of the Ebola outbreak.
Whilst our understanding of drug resistant Plasmodium falciparum is quite well understood, the extent and nature of resistance in Plasmodium vivax parasites is for the most part unknown.
Are you a research scientist working in Global Health? Or an institution looking for partners to run a clinical trial? Site Finder is for you.
International Severe Acute Respiratory and Emerging Infection Consortium newsletters
Documents for seeking ISARIC endorsement for research studies.
If you wish to join ISARIC you need to download and submit a membership form. Please download your form here.
ISARIC's Governance Framework v.4.2 as reviewed and ratified by ISARIC's Council 3 July 2014.
Professor Peter Piot, LSHTM, talks about Ebola and implications for Africa and understanding future epidemics at the Martin School, University of Oxford, 16th October 2014.
Access the WHO/ISARIC Clinical Characterisation Protocol for Severe Emerging Infection (v7), which is currently being rolled out in the UK. Site files for other countries will be made available in due course.
ESSENCE on Health Research have created a good practice document on research costing. It includes a review of the funding practices related to the definition and funding of direct and indirect costs.
This guide, developed by the WHO and released in December 2013, aims to facilitate implementation research in LMICs.
You can download protocols from a variety of sites implementing the ISARIC-SARI-BSProtocol by selecting the document from the list on the right.
ISARIC/WHO BSP sampling plan and CRF adapted by the Singapore Severe Acute Respiratory Infection Study Group, available for download.
This is the ISARIC case-report form if you wish to use it for cases of human infection with the novel coronavirus (hCoV-EMC).
A bibliography for articles that may be of interest when treating patients diagnosed with novel coronavirus.
A CRF aiming to provide feedback on the process to inform future work with ethical committees and regulatory agencies.
A collection of funding opportunities nationally, regionally and globally that may be of interest to ISARIC members. Please contact the Secretariat directly to suggest links for the next bulletin.
ISARIC - Inernational Severe Acute Respiratory and Emerging Infection Consortium broadcast a statement outlining proposals for a research agenda with regards to the novel coronavirus, through ProMED on December 8th. The statement includes a description of potential observatinal studies, RCTs, a sampling plan, and suggestions for possible interventions.
1st ISARIC Council Meeting Summary. Includes details on ISARIC's vision, a summary of the meeting proceedings and a list of the next steps ahead.
ISARIC's Newsletter for the first quarter of 2012, including and update of activities December 2011 - April 2012, a listing of the members of the Executive Committee, Regional Hubs, Working Groups, External Advisors and Secretariat, and a message from ISARIC's Chairman Jeremy Farrar.
ISARIC's Governance Framework describing the oranisational structure and the various tasks of the Executive Committee, Secretariat, Council, Working Groups, Advisory Committee and other entities that form part of ISARIC's governance framework.
ISARIC Membership forms for Full and Individual Membership with instructions.
All networks and individuals wishing to join ISARIC and wanting to participate in the activities of ISARIC's Working Groups must read and sign off the Membership Policy - including our mission statement and the objectives of the consortium. The Membership is applied for by filling out, signing, and submitting a membership form - either for Full Membership (Networks) or Individual Membership (individuals who are not, yet, eligible to represent networks). The membership is free of charge.